To make the Little Red Riding Hood costume wig I followed another online tutorial using pieces of long brown yarn and adding a few red pieces at my daughter’s insistence (for highlights). Since I don’t have a sewing machine, I hand sewed the yarn to the felt which was a bit tedious but worked. I knew it would be chilly enough that my daughter would need something to keep her head and ears warm, but I thought simply wearing a touque would take away from the costume, so I came up with a yarn wig that I think really gave the costume something special. Creating a Homemade WigĪgain, our Canadian weather came into play here. In hindsight, I probably should have sewed a piece of ribbon in, but the safety pin worked well enough for this Little Red Riding Hood costume. I attached some sticky Velcro pieces at the top to fasten it together, but the Velcro did not stick very easily, so I ended up just using a safety pin to keep it closed. ![]() Once I had the flannel cut, I used fabric glue to make the hood, attached it to the cape, and then glued a small seam around the edges to prevent fraying. ![]() I loosely followed a tutorial I found on the internet (Google it) to get the shape of the cape and how to do the hood. How to construct the cape pattern: If you know how to construct a half circle skirt, you're in luck Cause that's all this cape is. I bought a swatch of red flannel (I chose flannel purposely to act as a heavier layer, as Halloween can be quite cold here in Canada). Pen Chalk/Soap to mark your fabric Pins - they help hold your fabric The pattern is pretty simple and flexible with the way it needs to be drawn. ![]() We got a lot of compliments and it was a nice “girly” costume, which my daughter wanted, without being just another princess! Making Little Red Riding Hood’s Cape This homemade Little Red Riding Hood costume was a super sweet costume that did not take a lot of time or money.
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![]() His normal outfit consists of the standard male Domino Junior/Senior High uniform complete with a closed buckled collar. Yugi's character design was overseen by Kazuki Takahashi. Depicted here is the character in the full Domino School boy's regalia from front, side, and rear views and alongside views of his head from different angles. Yugi's design incorporates multiple layers of clothing and a wide range of expressions. Téa has been shown to have romantic feelings for both Yugi and Yami Yugi. Yugi has been friends with Téa since childhood and has a romantic crush on her. Yugi's friends often cheer him on from the sidelines, and Joey has dueled at his side. Yugi is part of a close-knit group of best friends: Joey Wheeler, Tristan Taylor, Téa Gardner and Bakura Ryou. He lives with his paternal grandfather, Solomon Muto, and his mother. ![]() Yugi was initially unaware of his existence and control of Yugi's body, and would involuntarily shift to Yami Yugi at trying times. ![]() Yugi possessed the three thousand-year-old (five thousand in the dub) mystical Millennium Puzzle, which allowed his body to bear host to the spirit of the Puzzle, Yami Yugi. Together with the spirit of Pharaoh Atem, he holds the title "King of Games" (King of Duelists in Japanese version). It was stated once that Yugi is the modern day version of Pharaoh Atem. Yugi Muto ( 武 ( む ) 藤 ( とう ) 遊 ( ゆう ) 戯 ( ぎ ) Mutō Yūgi), also romanized as Yugi Mutou, is the main protagonist of the original Yu-Gi-Oh! series, along with Yami Yugi. ![]()
![]() In this work I investigate the relationship between DNA replication and apparent mutation hotspots adjacent to transcription factor binding sites. It is important to understand these patterns of mutation as they influence where deleterious mutations are likely to arise and how rapidly sequences are likely to accumulate change between species, a measure often used as a proxy for functional constraint. Ce travail propose un panorama original des modifications du programme de réplication au cours de la différentiation normale ou pathologique, dont un contrôle lignée cellulaire spécifique des ZI dans les déserts de gènes à réplication tardive.The rate of DNA mutation is known to fluctuate across the genome but the patterns of mutation rate variation and molecular causes are poorly defined. Ceci nous conduit à quantifier le degré de dissociation entre ZI et activation de la transcription. En contraste, les dernières régions répliquées, à faible densité de gènes et pauvres en G+C, présentent peu de ZI efficaces, souvent spécifiques d'un tissu ou d'une lignée. ![]() Néanmoins, les régions riches en G+C et en gènes actifs, répliquées précocement au cours de la phase S, ont le programme de réplication le plus stable, elles présentent une forte densité de zones d'initiation de la réplication (ZI) efficaces et conservées entre lignées cellulaires. ![]() Il n’apparait pas de point chaud pour l’accumulation des changements réplicatifs, ceux-ci étant largement dispersés sur tout le génome. L'analyse comparative des profils OFR montre que les changements réplicatifs permettent la classification des lignées cellulaires en fonction de leur tissu d'origine, la nature cancéreuse ou non de la lignée n'intervenant qu'en second ordre. Nous proposons une caractérisation originale de la plasticité du programme de réplication de l’ADN se basant sur le profilage de 12 lignées cellulaires humaines normales ou cancéreuses par la méthode Ok-seq de purification et séquençage des fragments d'Okazaki qui permet de déterminer l'orientation de la progression des fourches de réplication (OFR) à haute résolution (10 kilo bases). Le programme spatiotemporel de réplication de l'ADN est régulé au cours du développement et altéré durant la progression cancéreuse. This work provides an original overview of replication program changes during normal or pathological differentiation, including a cell line specific control of IZ in late-replication gene deserts. This leads us to quantify the degree of dissociation between IZ and activation of transcription. In contrast, the late replicated, low gene density and low G+C content regions have few efficient IZs, often specific to a tissue or lineage. Nevertheless, the G+C rich and active gene regions, replicated early in the S phase, have the most stable replication program, they present a high density of efficient replication initiation zones (IZ) conserved between cell lines. There is no hotspot for the accumulation of replicative changes, they are widely dispersed throughout the genome. Comparative analysis of the RFD profiles shows that the replicative changes allow the classification of the cell lines according to their tissue of origin, the cancerous or non-cancerous nature of the cell line type intervening only in second order. We propose an original characterization of the plasticity of the DNA replication program based on the profiling of 12 normal or cancerous human cell lines by the Ok-seq method of purification and sequencing of Okazaki fragments which allows to determine the orientation of the progression of replication forks (RFD) at high resolution (10 kilo bases). The spatiotemporal program of DNA replication is regulated during development and altered during cancer progression. So it’s not so much which road you take, as how you take it.” – Charles de Lintĥ0) “Let’s go somewhere where nobody knows our name.” – Unknown 51) “Wanderlust and city dust.” - Unknown 52) “Good friends follow you anywhere.” – Winnie the Pooh You just have to decide when to take it.” – Chris Humphrey 49) “When all’s said and done, all roads lead to the same end. Go Instead Where There Is No Path And Leave A Trail.” – Ralph Waldo Emerson 48) “The open road is there, it will always be there. ![]() Seuss 46) “Always take the scenic route.”- Unknown 47) “Do Not Follow Where The Path May Lead. ![]() It’s all the wild stuff that happens along the way.” – Emma Chaseįriends definitely make the journey! One of my top short road trip quotes! 45) “Oh, the places you’ll go.” – Dr. 39) “Because the greatest part of a road trip isn’t arriving at your destination. 37) “To awaken alone in a strange town is one of the pleasantest sensations in the world.” – Freya Stark 38) “Every journey is simultaneously a beginning and an ending: I was leaving my old life behind and starting on a road trip to find a new me.” – Debi Tolbert DuggarĬan’t wait to share your fantastic road trip snaps with your followers? I can guarantee that these top Instagram captions about road trips will fit like a glove. This is one of my favorite road trip captions for Instagram 31) “Just grab a friend and take a ride together upon the open road.” – A Goofy Movie 32) “Discovery consists not in seeking new landscapes, but in having new eyes.” – Marcel Proustģ3) “Wherever you go becomes a part of you somehow.” - Anita Desai 34) “A bend in the road, is not the end of the road….unless you fail to make the turn.” – Helen Kellerģ5) “It’s a road trip! It’s about adventure! … It’s not like we have somewhere to go.” – John Green, An Abundance of Katherines 36) “Sometimes all you need is a great friend and a tank of gas.” – UnknownĪnd if they’re happy to split the cost of gas… even better. 10) “It’s not the destination, it’s the journey.” – Ralph Waldo Emerson 11) “You may not find a path, but you will find a way.” – Tom Wolfe 12) “People don’t take trips, trips take people.” – John Steinbeckġ3) “Take care of your car in the garage, and the car will take care of you on the road.” – Amit Kalantri 14) “Roads were made for journeys, not destinations.” – Confucius 15) “Roads are a record of those who have gone before.” – Rebecca Solnit 16) “Good company in a journey makes the way seem shorter.” – Izaak Waltonġ7) “The open road is a beckoning, a strangeness, a place where a man can lose himself.” – William Least Heat Moon 18) “If you don’t know where you are going, any road will get you there.” – Lewis Carrollġ9) “If you’re on a road trip, you need driving music.” -Edgar Wright 20) “The only impossible journey is the one you never begin” – Tony Robbins Short, sweet and succinct, these short road trip quotes truly encapsulate the power of an epic road trip. I don’t know where it’s going to lead me, but I follow it.” – Grace Jones Always take the adventure over the car! 9) “I just go with the flow, I follow the yellow brick road. I know my travel memories will last a lifetime. It has the good sense to go away, and you are left with nothing but a wonderful memory.” – Daniel Gilbert It will stay around to disappoint you, whereas a trip to Europe is over. But, in fact, that’s the worst thing about the new car. Not knowing where I’m going is what inspires me to travel it.” – Rosalia de Castroĭefinitely one of the most inspiring road trip captions for Instagram! 8) “Part of us believes the new car is better because it lasts longer. Just you and me.” – Unknown 7) “I see my path, but I don’t know where it leads. We’ll sing our hearts out, and we’ll make memories we’ll never forget. The highway, the radio, the blue sky, the back roads, and windows down. Have you read the classic about George and Lenny?Ħ) “I want to go on a road trip. Steinbeck’s ‘Of Mice and Men’ is a high school text so many of us study. ![]() We find that after years of struggle that we do not take a trip a trip takes us.” – John Steinbeck And all plans, safeguards, policing, and coercion are fruitless. ![]() Because stories are more important than things.” – Victoria Ericksonĥ) “A journey is a person in itself no two are alike. Then we’ll turn it into our own story that will live inside our history to carry with us, always. We’ll stop in every small town and learn the history and stories, feel the ground, and capture the spirit. This is one of my favorite road trip quotes! 4) “Road trips are the equivalent of human wings. ![]() Fonts must be downloaded before you can sample them. You can type your own text, change sizes, color and background. View a sample of the selected fonts on the right.Check the box next to a font to download and activate the font in one step.Gray fonts are on the server waiting to be downloaded. Fonts in dark print are already downloaded to your Mac.It remains downloaded on your Mac for next time. Click Deactivate to remove the font from your apps.Note: you need to quit and relaunch Microsoft to update font menus. Click Activate to add selected fonts to your apps.Select font families and click Download to keep the font on your Mac.Search for a font by name or other criteria by typing in the search box.Click Fonts to browse or search the entire font library.Click the triangle to the left of the server name to see the font library.Click the triangle to the left of the server name to see the font library underneath.īrowsing, previewing and activating fonts.Check the boxes to save the password and login automatically so you won’t have to type them again.Ask your administrator if you don’t know the password. Type your username (usually the first part of your email address) and.If you see a message that you need to reconnect, here’s how: The first time you open FontExplorer you may need to log in. If you have FontExplorer Pro, don’t use the OS X Font Book, Font Agent, Suitcase or other font apps which may interfere with FontExplorer Pro.ĭon’t have FontExplorer? You’ll need to download, install & license it before moving on to the next section. ![]() Search and browse fonts, download them to your Mac's FontExplorer, then preview and activate them to add to your font menus immediately.įontExplorer X Pro looks like a child’s toy block in the dock. You’ll use Linotype FontExplorer to access the master font library on the server. For stand-alone users, please see these instructions instead. Note: These instructions are for organizations using FontExplorer Server. FontExplorer stores all fonts on the server so every designer has exactly the same set of fonts. Search and browse fonts, then preview and activate them to add to your font menus immediately.
![]() The blue false indigo has violet-blue flowers that are about 1-2 inches long. When Does Blue False Indigo Bloomįalse indigo (Baptisia australis) is a herbaceous perennial that blooms in mid to late spring. In the summer, remove dead blooms and yellowing leaves from the plants to keep them looking their best. Pruning will keep the plant from becoming too large and will not necessitate it. Pruning Popular Landscape Plant False Indigoįalse indigo (Baptisia) is a popular landscape plant that can be pruned in a variety of ways to keep its shape and size in check. There is also the option of removing the spent flowers (deadheading), but you won’t enjoy the fluttering seed heads as autumn approaches. After blooming, you can trim the plant by about a third to shape it. In spring, all of the false indigo’s growth returns to its base, so there is no need to trim it. Do You Cut Back False Indigo In The Fall? In addition to being well suited to full sun and light shade, it is also tolerant of the majority of soils. False indigo is a shade blue flower that can be grown in any garden area and is easy to care for. The roots of this plant can grow to be up to 12 feet ( 3.5 meters) deep, and one or two clumps can grow to be 3 feet (1 meter) or 4 feet (1 m) wide. It will spread if not kept in check, but once planted, it will not tolerate being moved. False indigo is a wonderful blue shade that can be grown in almost any garden area. In general, it will tolerate most soils as long as they are well-drained, preferably gravelly, sandy, or well-drained. Because of the lower flower height, shade may be required if it does not bloom as profusely. However, in the shade, it will prefer to be in direct sunlight. False Indigo: The Easy To Care For Shade Blue Floweįalse indigo is a hardy perennial that will tolerate a slight shade of light. They are a shade-loving plant and will do best in an area that receives dappled sunlight or full shade. Do Blue False Indigo Need Full Sun?ĭo blue false indigo need full sun? No, they do not. It prefers fertile, well-drained soil, moderate moisture, and full sun, with the exception of very hot climates, where it can appreciate some afternoon shade. Tinctoria indigo is hardy in USDA zones 10 and 11. In USDA zones 10 and 11, it grows as an evergreen. Where does indigo grow and where should it be grown? Indigo plants are simple to care for. You can start propagating indigo seeds by soaking them in water overnight. If you do not live in a warm climate, you will require a greenhouse, a warm, sunny window, or even a heated propagator to grow the best plants. How hard is it to grow indigo from seed? Indigo seeds can be grown from seed, but they need some form of heat to grow. If you don’t want to disturb the seed heads in the fall breeze, you can also remove the spent flowers (deadheading). After blooming, you can shape the plant by cutting it back by one-third of its original size. Why do we not cut the indigo in the fall? True indigo has no need for trimming because the base is always growing again in spring. No, Pruning Is Not Necessary For False Indigo When your perennial is growing in a very fertile potting mix, you may notice leaves and stems rather than flowers growing. Choosing a planting mix that will provide good drainage for your perennial is an important consideration in these circumstances. Furthermore, perennial plants may be less prone to insect and disease problems than annuals. You may also enjoy their flowers for a longer period of time if they bloom earlier. It is one thing to plant perennial flowers it is quite another to plant them for an extended period of time. Perennial plants should be included in your garden for a variety of reasons. If you have any questions, please call Customer Service toll-free at (877) 309-7333 or contact us by email.Indigo is a perennial plant that requires only half the leaves to survive for more than a year, so harvest them only when they are plentiful. See our shipping information page for approximate ship dates and more detailed information. If your order requires more than one shipment and all items are shipping to the same address, there is no additional shipping charge. Perennial and spring-planted bulb orders will arrive separately from seeds. Perennials and spring-planted bulbs are shipped at the proper planting time for your hardiness zone. Please open upon receipt and follow the instructions included. All perennials and spring-planted bulbs are packaged to withstand shipping and are fully-guaranteed. The ‘Plant Information’ section describes how that item will ship. Some perennials are shipped as potted plants, some as perennial roots packed in peat. You will receive a second email the day your order ships telling you how it has been sent. As soon as your order is placed you will receive a confirmation email. Resting the dough will allow the gluten that has formed (hopefully not much!) to relax and it will also chill the butter so that it is more firm. But your dough will need a rest in the refrigerator! You won’t have to work very hard to make shortbread – it honestly comes together really quickly and easily. Kerrygold is generally pretty easy to find in the US but if you can’t find it, use what you have! Rest, rest, rest that dough! (No, this post is not sponsored!) I always use it in recipes where quality butter is needed, like puff pastry and shortbread. But the higher the quality, the lower the water content so there will be variations in the final product! My favorite butter is Kerrygold. If you do use a lower quality butter, your shortbread will still be delicious. And this recipe uses a lot of it! You will want to use the highest quality butter that you can afford, especially for a recipe that highlights butter! It should be short, meaning that it has a high proportion of fat to flour causing it to crumble and no gluten development! Better butter is best in Scottish Shortbread! If the dough is overworked, it will be tough and chewy – the exact opposite of what you want!Ī good Scottish shortbread recipe should yield cookies that are crumbly and sandy and melt in your mouth. Do not knead the dough!īy handling it with care, you are minimizing the development of gluten in the dough. Then use your hands to gather the dough so that it stays in one piece. Don’t worry, it’s not hard!įirst, handle with care! You do not want to overwork the dough, either in the mixer or by hand! Mix only until the dough begins to stick together and then dump the dough on the counter. There are a couple of tricks to keep in mind when making Scottish shortbread. It just doesn’t need anything else!Ĭherries and chocolate flavor this buttery shortbread. ![]() I’ve seen and tried variations like using cornstarch in place of some of the flour or icing sugar in place of some of the granulated sugar.īut I keep coming back to the same recipe. I do add a little salt and vanilla to increase the flavor. That’s all you need for a traditional shortbread recipe. You can mix in some extras if you would like to flavor your shortbread but why mess with a classic? Scottish Shortbread Recipe with just a few simple ingredients…īutter. ![]() Scottish Shortbread is simple to make and only requires a few ingredients. Now don’t get me wrong – I love all cookies! But if I had to choose one cookie to keep in my cookie jar at all times, it would be Traditional Scottish Shortbread. There is just nothing better than a simple, buttery, classic shortbread when a cookie craving strikes! So today I am sharing my Traditional Shortbread Recipe! But, I have to admit, I’m a purest and I love Classic Scottish Shortbread. ![]() Some people like their cookies packed with chocolate chips, fruit, marshmallows, etc. ![]() However, the heart defects associated with CCHD can also occur as part of genetic syndromes that have additional features. Researchers believe that single-gene mutations and copy number variation account for a relatively small percentage of all CCHD.ĬCHD is usually isolated, which means it occurs alone (without signs and symptoms affecting other parts of the body). However, it is unclear whether genes affected by copy number variation are involved in heart development and how having missing or extra copies of those genes could lead to heart defects. Studies have also suggested that having more or fewer copies of particular genes compared with other people, a phenomenon known as copy number variation, may play a role in CCHD. Most of the identified mutations reduce the amount or function of the protein that is produced from a specific gene, which likely impairs the normal formation of structures in the heart. Studies suggest that these genes are involved in normal heart development before birth. A variety of genetic and environmental factors likely contribute to this complex condition.Ĭhanges in single genes have been associated with CCHD. In most cases, the cause of CCHD is unknown. The heart defects classified as CCHD include coarctation of the aorta, double-outlet right ventricle, D-transposition of the great arteries, Ebstein anomaly, hypoplastic left heart syndrome, interrupted aortic arch, pulmonary atresia with intact septum, single ventricle, total anomalous pulmonary venous connection, tetralogy of Fallot, tricuspid atresia, and truncus arteriosus. People with CCHD have one or more specific heart defects. Still others involve a combination of these structural abnormalities. Others affect the structure of the large blood vessels leading into and out of the heart (including the aorta and pulmonary artery). Some of the heart defects involve structures within the heart itself, such as the two lower chambers of the heart (the ventricles) or the valves that control blood flow through the heart. Adults with these heart defects have an increased risk of abnormal heart rhythms, heart failure, sudden cardiac arrest, stroke, and premature death.Įach of the heart defects associated with CCHD affects the flow of blood into, out of, or through the heart. However, long-term effects of CCHD can include delayed development and reduced stamina during exercise. Some people with treated CCHD have few related health problems later in life. However, most people with CCHD now survive past infancy due to improvements in early detection, diagnosis, and treatment. If untreated, CCHD can lead to shock, coma, and death. ![]() These can include an abnormal heart sound during a heartbeat (heart murmur), rapid breathing (tachypnea), low blood pressure (hypotension), low levels of oxygen in the blood (hypoxemia), and a blue or purple tint to the skin caused by a shortage of oxygen (cyanosis). ![]() Individuals with CCHD usually require surgery soon after birth.Īlthough babies with CCHD may appear healthy for the first few hours or days of life, signs and symptoms soon become apparent. As a result, organs and tissues throughout the body do not receive enough oxygen, which can lead to organ damage and life-threatening complications. CCHD prevents the heart from pumping blood effectively or reduces the amount of oxygen in the blood. These abnormalities result from problems with the formation of one or more parts of the heart during the early stages of embryonic development. Patients with interrupted aortic arch are evaluated by a geneticist to determine if they have DiGeorge syndrome.Critical congenital heart disease (CCHD) is a term that refers to a group of serious heart defects that are present from birth. Patients with DiGeorge syndrome can have cranio-facial, immune and electrolyte abnormalities in addition to their congenital heart disease. Interrupted aortic arch is commonly seen as a result of a genetic chromosomal microdeletion (chromosome 22q11), often referred to as DiGeorge syndrome. The prognosis and treatment for the patient with IAA will be affected by the presence of any associated defects. Interrupted aortic arch usually occurs with other cardiac anomalies, such as ventricular septal defects, patent ductus arteriosus, transposition of the great arteries, aortic stenosis, truncus arteriosus, bicuspid aortic valve, and atrioventricular canal defects. If steps are not taken to keep the Patent Ductus Arteriosus (PDA) open, no oxygen will make its way to the lower body tissues and the patient will go into shock. An infant with this anomaly is usually quite sick immediately after birth. |